منابع مشابه
Regular Manuscript Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML) Short title: NPM1 mutations in AML - Scientific Section: NEOPLASIA
Mutations of the Nucleophosmin (NPM1) gene have recently been described in patients with AML. To clarify the prevalence as well as the clinical impact of this mutation, we investigated 1485 patients with AML for NPM1 exon 12 mutations using fragment analysis. A 4-bp insert was detected in 408/1485 patients (27.5%). Sequence analysis revealed known mutations (Type A, B, and D) as well as 13 nove...
متن کاملIncidence and Prognostic Value of NPM1 and FLT3 Gene Mutations in AML with Normal Karyotype
NPM1 belongs to a new category of genes that function both as oncogenes and tumor suppressor genes, depending on gene dosage, expression levels, interacting partners, and compartmentalization. Nucleophosmin mutations within exon 12 have been described as the most frequent acquired molecular abnormalities in adult and pediatric acute myeloid leukaemia (AML), mutation can be observed in nearly ha...
متن کاملPrevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).
Mutations of the nucleophosmin (NPM1) gene have recently been described in patients with acute myeloid leukemia (AML). To clarify the prevalence as well as the clinical impact of this mutation, we investigated 1485 patients with AML for NPM1 exon 12 mutations using fragment analysis. A 4 bp insert was detected in 408 of 1485 patients (27.5%). Sequence analysis revealed known mutations (type A, ...
متن کاملNPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS).
Mutations in the NPM1 gene represent the most frequent genetic alterations in patients with acute myeloid leukemia (AML) and are associated with a favorable outcome. In 690 normal karyotype (NK) AML patients the complete remission rates (CRs) and the percentage of patients with adequate in vivo blast cell reduction 1 week after the end of the first induction cycle were significantly higher in N...
متن کاملSplicing factor mutations in AML.
heralds a new era of targeted therapies for the management of this disease. The drug is generally well tolerated with mostly mild side effects that frequently resolve despite continuation of therapy. The responses observed are primarily sustained partial responses with occasional complete responses, which appear to be independent of conventional prognostic markers. Similar results were also see...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v126.23.2592.2592